Intense Replenishing Serum
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Primes, soothes and protects skin.

This hydrating serum plumps skin appearance while increasing luminosity and smoothness. Antioxidant Lipochroman® protects against free radical damage caused by pollution and UV radiation - the leading causes of fine lines and age spots. Glycolipids replenish moisture loss caused by climate conditions, while vitamins E and F calm skin redness.


✩✩✩✩✩    "I love to slather on this serum to plump my skin, while also fighting free radicals via its powerful antioxidant, Lipochroman®." 
1 fl oz / 30 mL
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  • Pollution: Lipochroman®, the strongest of all antioxidants, provides your skin with maximum pollution protection.
  • Light: Lipochroman®, Vitamin E and linoleic acid protect against free radical damage caused by UV radiation.
  • Climate: Glycolipids, lecithin and linoleic and linolenic acids trap moisture into skin surface to keep skin well hydrated even in drier colder conditions or after exfoliants and peels.
  • Irritants: Intense Replenishing Serum is soothing and can be used on sensitive and post-procedure skin. Like all Dr. Loretta products, it's free of potential irritants including artificial fragrance, dye, parabens and phthalates.

Protocol: Results may vary. Average results shown. Study conducted on female subjects ages 34 to 62. For controlled results, females used Dr. Loretta's 3-step Intense Brightening Regimen (Micro-Exfoliating Cleanser, Intense Replenishing Serum, and Intense Brightening Cream) twice daily for 12 weeks. 

Key Ingredients:

  • Bioidentical Skin Lipids: Replenish moisture to provide instant radiance and keep skin well-hydrated even in dry, colder environments.
  • Antioxidant Lipochroman®: One of the strongest antioxidants in skincare, protects from pollution including oxygen, nitrogen, and carbon free radical damage and tiny particles of urban dust known to damage skin cells and promote wrinkles and age spots.
  • Vitamin F (Linoleic and Linolenic acids) and Lecithin: Skin essential oils that are vital to a healthy skin barrier as they prevent water loss from skin surface.

Cyclopentasiloxane, Ethylhexyl Cocoate, Dimethiconol, Phenoxyethanol, Glyceryl Linoleate, Glyceryl Linolenate, Tocopheryl Acetate, Glycolipids, Lecithin, Dimethylmethoxy Chromanol.

After cleansing, apply to face, neck and back of hands. This serum can also be mixed with any of our other Dr Loretta serums in the palm of the hand and then applied to treatment areas to boost skin hydration.  Follow with our Dr. Loretta® moisturizers. Use AM and PM. Always finish your regimen with Urban Antioxidant Sunscreen in the morning.

How to Use Dropper

  1. Unscrew cap.

  2. Squeeze bulb for 3 seconds.

  3. Release bulb.

  4. Remove dropper and squeeze to dispense.

Customer Reviews
4.8 Based on 28 Reviews
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A Dr. Loretta Customer
Darcy W.
United States United States
Seriously soft skin

This serum has alleviated the flakiness of my skin due to retinoids and makes it SO smooth and silky feeling. Will definitely be a staple in my routine henceforth.

A Dr. Loretta Customer
Miranda R.
United States United States
Not for my skin

I love Dr. Loretta. I am 36 aand have been using the anti aging repair moisturizer for a year or so. I wanted to try the replenishing serum and brightening cream. I used it for 3 days and with every use my skin felt like tiny inflamed needles and I was breaking out. I passed it along to my 65 year old mother. I am confident it’s a great product, just wasn’t correct for my skin. I usually don’t have sensitive skin....! I will continue to use the anti aging line.

Raven C.
United States United States
Love this serum!

I love using this serum every morning!

A Dr. Loretta Customer
United States United States
Like a cashmere sweater for your face!

I have good genes, age 33, but spent too many years smoking and sunning. This serum has leveled me up though. I have noticed a difference in texture for sure, and it is so hydrating! It also helps my skin deal with adjusting to retinol, so I have been able to use my retinol more often. Pricey but worth every drop.

Maggie B.
United States United States
Must have!!

The Intense replenishing serum is a must have. It has made my dry skin feel smooth and soft. I love it!